Running with SteamVR + Proton the game has severe flickering issues in certain areas.
The native port does not have those but is borked ootb because of an outdated library.
To be able to run it I had to install gperftools
and replace the game library with the system one by doing the following in the HLA root dir:
rm game/bin/linuxsteamrt64/libtcmalloc_minimal.so.0
cp /usr/lib/libtcmalloc_minimal.so.4.5.5 game/bin/linuxsteamrt64/libtcmalloc_minimal.so.0
See here for more info: https://steamcommunity.com/app/546560/discussions/0/4042608198327331164/
Keep in mind some workshop maps do not work with the native Vulkan version sadly (like Post-Human for example).
Monado + OpenComposite + Proton did not have flickering issues, but graphic rendering seemed a bit off.
Performance was a bit stuttery as well.