Did not work out of the box, but by changing which compatibility library was used in WiVRn and which Proton version was used in Steam, I finally got vanilla to work! Modded skyrim may be achievable but I am struggling with getting MO2 to work using Furglitch's linux installer.
Notes:
- Use deb installation of Steam
- Use Open Composite for compatibility library, at least as of the time written. Xrizer nightly version would be preferred but currently cannot work by itself as it has no keyboard functionality and you are not able to get past character creation without setting your name
- Use Proton 9. Only version I had success with and it also happened to be recommended by the linux installer I have tried to use